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  • Chemical Biology

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    Here’s some medicinal chemistry combined with synthetic biology for you. Many people are used to thinking in terms of finding small-molecule probes for various cell targets, and those are valuable things. But what if you want to control a certain population of (for example) ion channels, but there aren’t any compounds that will do the… 1 48-GIIC MODELS - EMBRAER T-27 AT-27 Tucano - FAB -FULLY DETAILED
  • Chemical News

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    FUJIMI SCHNITZER BMW S5 1 24th Scale model Kit RARE I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Hobbyboss Model 86505 1 350 French Navy Pre-Dreadnought Battleship Condorcet
  • Analytical Chemistry

  • Cancer

  • Drug Assays

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    Dioramas FAQ book by Rubén González - AK8000 A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Dragon 1 35 LCSS Light Seal Support Craft
  • Academia (vs. Industry)

    Startup Culture, Starting

    Andrea Eisernes Kreuz German HG Panzer Officer 1943 WW2 1 16th Unpainted kit Many readers of this blog work in the biopharma industry, naturally, and of those, many are in and around the (few) locations where a great many of the companies in the industry are born. I myself am in the Boston/Cambridge area, famously thick with companies large and small, and then you have the Bay area… Trumpeter 1 700 USS Maryland BB-46 1945
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