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  • Chemical Biology

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    Here’s some medicinal chemistry combined with synthetic biology for you. Many people are used to thinking in terms of finding small-molecule probes for various cell targets, and those are valuable things. But what if you want to control a certain population of (for example) ion channels, but there aren’t any compounds that will do the… Paragrafix PGX211 2001 A Space Odyssey 1 144 Discovery XD-1 Pod Bay Photoetch
  • Chemical News

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    AMT Star Trek U.S.S. Enterprise Cut-away Model Kit NCC-1701 Model 8790 sealed I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Magna 1 48 1148 MILES MASTER Mk.IA
  • Analytical Chemistry

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    I suppose I deserve this one. Some years ago on the blog, I wrote about my days in grad school having to learn about symmetries and vibrational spectroscopy. Sparingly has that knowledge come in handy since then, but the course is still a vivid memory for me, since that’s the clearest example I had yet… Read More
  • Cancer

  • Drug Assays

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    Tamiya 1 700 Repulse 31617 A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

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    A scientific giant, Sydney Brenner has died at the age of 92. He was present at the beginning of molecular biology – while in the chemistry department at Oxford, he car-pooled with Dorothy Hodgkin, Leslie Orgel, Jack Dunitz and others over to Cambridge to see Watson and Crick’s new model for the structure of DNA… 1 72 Unicraft Kogiken Plan V
  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… C18-Caproni Ca.3, Ca.4220-Chgoldszy Modelbud-1 72
  • Academia (vs. Industry)

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