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  • Chemical Biology

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  • Chemical News

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    KING AND COUNTRY THE REAL WEST - Running Deer - Sioux warrior TRW045(P) I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… NEW TAMIYA 23211 1 12 Collector's Club Special No. 11 Ferrari 288GTO from JAPAN
  • Analytical Chemistry

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    I suppose I deserve this one. Some years ago on the blog, I wrote about my days in grad school having to learn about symmetries and vibrational spectroscopy. Sparingly has that knowledge come in handy since then, but the course is still a vivid memory for me, since that’s the clearest example I had yet… Read More
  • Cancer

  • Drug Assays

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    BRITAINS DEETAIL DISMOUNTED 7TH CAVALRY WITH CUSTER - TOY SOLDIERS - SET OF SIX A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Timpo Mounted Cowboy Masked Bandit No 1
  • Academia (vs. Industry)

    Startup Culture, Starting

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